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. 2026 Mar 27;17:1788432. doi: 10.3389/fendo.2026.1788432

Figure 4.

Figure with three panels of dot plots and box plots analyzing gene expression data. Panel A shows box plots comparing GLP-1R and INS gene expression across NGF, RHC, and OTHER INT tissues in groups with and without tumor. Panel B presents scatter plots of GLP-1R gene expression against blood sugar level across the three tissue types, with a dashed trend line in each. Panel C features scatter plots comparing GLP-1R and INS gene expression in the three tissues, each with a dashed diagonal reference line. Each data point uses different colors for visualization.

(A), Comparison of INS (bottom) and GLP1R (top) mRNA expression in cells collected from patients with brain tumours to those with hydrocephalus or aneurysm (without tumour). (B), GLP1R mRNA expression in neurogliaform (NGF), rosehip (RHC) and other cells according to blood glucose levels. No significant differences in INS or GLP1R copy numbers were found across cell types based on actual glycaemia. (C) Strong correlation between INS and GLP1R copy number in NGFs (p<0.001), and a trend in RHCs (p=0.059) was revealed by Pearson correlation analysis.