TABLE 2.
Comparison of clinical characteristics between pCR group and non-pCR group in the training cohort.
| Variables | Total (n = 178) | pCR group (n = 132) | Non-pCR Group (n = 46) |
Statistic | P |
|---|---|---|---|---|---|
| Age (year) | 56.55 ± 12.31 | 58.56 ± 11.43 | 50.78 ± 13.03 | t = 3.83 | < 0.001 |
| Pre-weight (kg) | 61.15 ± 9.80 | 61.38 ± 9.62 | 60.51 ± 10.38 | t = 0.52 | 0.604 |
| Pre-TP (g/L) | 70.25 ± 5.38 | 70.18 ± 5.31 | 70.46 ± 5.64 | t = −0.29 | 0.768 |
| Pre-ALB (g/L) | 40.53 ± 3.83 | 40.65 ± 3.85 | 40.18 ± 3.80 | t = 0.72 | 0.472 |
| Pre-PA (mg/L) | 229.93 ± 70.51 | 229.97 ± 70.95 | 229.82 ± 69.99 | t = 0.01 | 0.990 |
| AGR | 1.39 ± 0.27 | 1.41 ± 0.27 | 1.35 ± 0.27 | t = 1.39 | 0.166 |
| Post-weight (kg/L) | 60.49 ± 9.36 | 60.08 ± 9.29 | 61.67 ± 9.56 | t = −1.00 | 0.321 |
| Post-HGB (g/L) | 109.41 ± 20.21 | 107.37 ± 20.72 | 115.28 ± 17.58 | t = −2.31 | 0.022 |
| Post-PA (mg/L) | 235.97 ± 75.08 | 225.60 ± 74.87 | 265.72 ± 68.09 | t = −3.20 | 0.002 |
| Post-AGR | 1.30 ± 0.27 | 1.30 ± 0.28 | 1.29 ± 0.21 | t = 0.46 | 0.648 |
| ΔTP | 0.11 ± 7.75 | −0.62 ± 7.96 | 2.20 ± 6.76 | t = −2.14 | 0.033 |
| Pre-HGB (g/L) | 120.15 (101.00, 133.20) | 120.00 (98.45, 132.00) | 122.70 (104.05, 140.50) | Z = −0.63 | 0.529 |
| Pre-Glo (g/L) | 29.15 (27.00, 32.25) | 29.05 (27.08, 31.70) | 29.95 (26.48, 33.10) | Z = −1.03 | 0.305 |
| Pre-LogCEA | 0.80 (0.48, 1.24) | 0.77 (0.49, 1.18) | 0.91 (0.43, 1.36) | Z = −0.57 | 0.569 |
| Pre-LogCA199 | 0.89 (0.51, 1.42) | 0.90 (0.50, 1.38) | 0.81 (0.53, 1.56) | Z = −0.44 | 0.658 |
| Pre-GNRI | 104.45 (97.89, 109.31) | 105.87 (98.47, 109.57) | 100.71 (95.93, 107.85) | Z = −1.90 | 0.057 |
| Post-TP (g/L) | 70.70 (66.40, 74.75) | 70.25 (65.90, 74.23) | 72.15 (68.88, 76.65) | Z = −2.53 | 0.011 |
| Post-ALB (g/L) | 39.50 (36.35, 42.55) | 38.90 (35.98, 42.30) | 41.05 (37.75, 43.10) | Z = −2.30 | 0.021 |
| Post-Glo (g/L) | 30.85 (27.30, 34.27) | 30.30 (26.87, 34.35) | 32.00 (28.52, 34.03) | Z = −1.52 | 0.128 |
| Post-LogCEA | 0.53 (0.35, 0.74) | 0.56 (0.37, 0.80) | 0.47 (0.28, 0.54) | Z = −3.30 | < 0.001 |
| Post-LogCA199 | 0.86 (0.47, 1.18) | 0.85 (0.46, 1.26) | 0.90 (0.52, 1.09) | Z = −0.14 | 0.890 |
| Post-GNRI | 102.86 (95.82, 107.88) | 102.41 (94.56, 107.46) | 103.51 (99.38, 108.89) | Z = −1.47 | 0.141 |
| ΔHGB | −6.35 (−16.97, 3.10) | −8.70 (−17.20, 3.00) | −2.00 (−15.73, 8.30) | Z = −1.70 | 0.088 |
| ΔALB | −1.40 (−4.30, 1.48) | −2.00 (−4.82, 0.60) | 0.45 (−3.60, 2.82) | Z = −2.87 | 0.004 |
| ΔGlo | 1.25 (−1.87, 4.90) | 0.75 (−1.55, 4.17) | 3.10 (−2.38, 5.40) | Z = −1.10 | 0.273 |
| ΔPA | 7.05 (−31.35, 49.50) | 0.00 (−47.20, 33.55) | 26.05 (−18.67, 75.58) | Z = −3.10 | 0.002 |
| ΔCEA | −1.39 (−12.67, 0.63) | −0.91 (−7.88, 1.12) | −5.03 (−20.00, 0.11) | Z = −2.65 | 0.008 |
| ΔLogCEA | −0.17 (−0.58, 0.04) | −0.10 (−0.48, 0.04) | −0.39 (−0.91, 0.03) | Z = −2.23 | 0.026 |
| ΔCA199 | 0.00 (−10.07, 2.04) | 0.00 (−6.76, 2.13) | −0.00 (−22.31, 1.49) | Z = −1.06 | 0.290 |
| ΔLogCA199 | 0.00 (−0.34, 0.15) | 0.00 (−0.33, 0.15) | −0.00 (−0.51, 0.12) | Z = −0.89 | 0.375 |
| ΔGNRI | −2.42 (−7.26, 2.43) | −4.15 (−9.08, 0.36) | 2.39 (−2.68, 4.91) | Z = −3.98 | < 0.001 |
| ΔAGR | −0.09 (−0.23, 0.04) | −0.09 (−0.23, 0.03) | −0.08 (−0.20, 0.03) | Z = −0.41 | 0.679 |
| Sex, n(%) | χ2 = 0.82 | 0.364 | |||
| Male | 118 (66.29) | 85 (64.39) | 33 (71.74) | ||
| Female | 60 (33.71) | 47 (35.61) | 13 (28.26) | ||
| Smoking, n(%) | χ2 = 0.06 | 0.809 | |||
| No | 111 (62.36) | 83 (62.88) | 28 (60.87) | ||
| Yes | 67 (37.64) | 49 (37.12) | 18 (39.13) | ||
| Drinking, n(%) | χ2 = 0.67 | 0.414 | |||
| No | 119 (66.85) | 86 (65.15) | 33 (71.74) | ||
| Yes | 59 (33.15) | 46 (34.85) | 13 (28.26) | ||
| Hypertension, n(%) | χ2 = 3.28 | 0.070 | |||
| No | 147 (82.58) | 105 (79.55) | 42 (91.30) | ||
| Yes | 31 (17.42) | 27 (20.45) | 4 (8.70) | ||
| T stage, n(%) | χ2 = 2.43 | 0.119 | |||
| T3 | 110 (61.80) | 86 (65.15) | 24 (52.17) | ||
| T4 | 68 (38.20) | 46 (34.85) | 22 (47.83) | ||
| N stage, n(%) | −- | 0.477 | |||
| N0 | 3 (1.69) | 2 (1.52) | 1 (2.17) | ||
| N1 | 65 (36.52) | 51 (38.64) | 14 (30.43) | ||
| N2 | 110 (61.80) | 79 (59.85) | 31 (67.39) | ||
| Location, n(%) | χ2 = 1.23 | 0.268 | |||
| Right | 131 (73.60) | 100 (75.76) | 31 (67.39) | ||
| Left | 47 (26.40) | 32 (24.24) | 15 (32.61) | ||
Pre-weight, pre-treatment weight; Pre-HGB, hemoglobin concentration; Pre-TP, pre-treatment total protein concentration; Pre-ALB, pre-treatment albumin concentration; Pre-PA, pre-treatment prealbumin concentration; Pre-Glo, pre-treatment globulin concentration; Pre-AGR, pre-treatment albumin-toglobulin ratio; Pre-GNRI, pre-treatment Geriatric Nutritional Risk Index; Pre-LogCEA, pre-treatment LogCEA; Post-weight, post-treatment weight; Post-HGB, post-treatment hemoglobin concentration; Post-TP, post-treatment total protein concentration; Post-ALB, post-treatment albumin concentration; Post-PA, post-treatment prealbumin concentration; Post-Glo, post-treatment globulin concentration; Post-AGR, post-treatment albumin-toglobulin ratio; Post-GNRI, post-treatment Geriatric Nutritional Risk Index; Post-LogCEA, post-treatment LogCEA; Δx = post-treatment value—pre-treatment value. Bold values indicate P < 0.05, which is considered statistically significant.