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. 2026 Mar 27;17:1786040. doi: 10.3389/fimmu.2026.1786040

Figure 3.

Four retinal fundus images labeled A through D are arranged in a two-by-two grid. Image A shows a retina with extensive scarring, hemorrhage, and pale lesions. Image B is a grayscale fundus photograph highlighting an area of central hyperreflectivity with mottled texture. Image C displays a healthy retina with normal vasculature, clear optic disc, and no visible lesions. Image D reveals retinal atrophy, marked pigment changes, and patches of white and red lesions radiating from the optic disc.

(A) Retinography of the LE obtained prior to CAR-T and after diagnostic vitrectomy, followed by four intravitreal methotrexate injections. This image shows the absence of vitreous inflammation; the white spots were retinal laser scars. The biopsy was conducted in an eye affected by media opacity due to vitreous bleeding and exudative retinal detachment, so laser photocoagulation was mandatory. Additionally, there are residual preretinal hemorrhages post-surgery. (B) Fundus autofluorescence imaging of the LE demonstrating central retinal atrophy, correlating with the patient’s persistent visual impairment. (C) Retinography of the RE showing a normal retinal appearance without inflammatory or infiltrative changes. (D) Retinography of the LE after CART therapy showing complete resolution of vitritis, hemorrhages, and retinal detachment.