TABLE 2.

Distribution of differences in MICs for 107 Aspergillus isolates and percent agreement within 3 dilutions for the E-test and M38-P method

Fungus (no. of isolates tested)	Antifungal agenta	Incubation time	No. of isolates with E-test MICs different from the NCCLS M38-P method MICs							% Agree- mentb
			>+2	+2	+1	0	−1	−2	>−2
A. flavus (15)	V	24 h			3	6	2	3	1	93.3
		48 h		2	1	5	7			100
	P	24 h		2	2	7	3	1		100
		48 h		7	5	1	1	1		100
	I	24 h		3	5	4	3			100
		48 h		7	4	4				100
	A	24 h	3	3	3	3		2	1	73.3
		48 h	11	3	1					26.7
A. fumigatus (62)	V	24 h		4	26	27	1	2	2	96.8
		48 h	1	6	30	22	1	2		98.3
	P	24 h	2			17	35	4	4	90.3
		48 h	2	3	34	14	7	1	1	95.2
	I	24 h	5	10	15	22	7	2	1	90.3
		48 h	16	11	18	16	1			74.2
	A	24 h		4	12	14	22	8	2	96.7
		48 h	22	15		7	18			64.5
A. nidulans (10)	V	24 h		1	1	1	2	2	3	70
		48 h		1	1	2	1	2	3	70
	P	24 h			2		6		2	80
		48 h		1	5		2		2	80
	I	24 h		1	2	1	4		2	80
		48 h		2	1		5		2	80
	A	24 h	1	2		2	3	1	1	80
		48 h	4		2	4				60
A. niger (10)	V	24 h				1	7	2		100
		48 h			1	3	5	1		100
	P	24 h			1	3	3	2	1	90
		48 h		3	5	2				100
	I	24 h			1	9				100
		48 h		1	9					100
	A	24 h			2	5	3			100
		48 h			3	7				100
A. terreus (10)c	V	24 h								N/A
		48 h			6	1	3			100
	P	24 h								N/A
		48 h			4	4	2			100
	I	24 h								N/A
		48 h	1	2	1	2	1	3		90
	A	24 h								N/A
		48 h	3	3	2	2				70
All isolates (107)	V	24 h		5	30	35	12	9	6	93.8
		48 h	1	15	34	34	15	5	3	96.3
	P	24 h	2	2	5	33	41	7	7	90.7
		48 h	2	14	53	23	10	2	3	95.3
	I	24 h	5	14	23	36	14	2	3	91.8
		48 h	17	23	33	22	7	3	2	82.2
	A	24 h	5	9	17	24	28	11	3	91.7
		48 h	38	20	9	20	20			64.5

^aV, voriconazole; P, posaconazole; I, itraconazole; A, amphotericin B.

^bPercentage of MICs obtained by the two methods that were within 3 dilutions.

^cN/A, not applicable; five to six isolates did not grow well at 24 h.