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. 2005 Dec 5;102(50):18129–18134. doi: 10.1073/pnas.0505256102

Fig. 2.

Fig. 2.

Mucosal inflammation and expression of PC defensin HD5. (A) Correlation of mucosal inflammation and the proinflammatory cytokine IL-8 mRNA levels in ileal CD and non-IBD controls. Hematoxylin/eosin-stained paraffin sections from specimens were assessed for mucosal inflammation by a gastrointestinal pathologist who was uninformed about samples [no inflammation (0), moderate (1), and severe (2)]. IL-8 mRNA expression levels, expressed as mRNA copies per 10 ng of RNA [means (±standard error) shown for each group]. Inset shows the average inflammation score for controls (n = 8) and ileal CD patients (n = 25). (B) Expression of HD5 mRNA in specimens from non-IBD controls and patients with ileal CD grouped as in A. Data expressed as mRNA copy number per 10 ng RNA (means ± standard error), from same specimens as analyzed in Fig. 1C. (C) Expression of IL-8 mRNA in specimens from normal and inflamed ileal pouches. Biopsy specimens were from normal (n = 7) and inflamed pouch mucosa (pouchitis, n = 7). IL-8 mRNA expression levels are expressed as in A. The significance values based on the Mann–Whitney test (*, P < 0.05). (D) Expression of HD5 mRNA in the same specimens as in C. A similar pattern was observed for HD6 (data not shown).