FIG. 5.

Profile analysis of the 2HCT family of transporters. The profiles were calculated based upon a multiple-sequence alignment of the “typical” sequences listed in Table 1, using a window of 20 residues (see also the legend to Fig. 1). Bars in the tops of the panels indicate the positions of gaps in the sequences. (A) Hydropathy profile using the Eisenberg scale (38). (B) Pairwise sequence identity (PSI) profile. The fraction of identical pairs at each position averaged over the window is plotted. (C) Hydrophobic moment profile. The hydrophobic moment was calculated at a periodicity of 100^o (α-helix). (D) Frequency distribution of the glycine, alanine, and serine residues.