Table 2.
Descriptive analysis of the sample according to the final diagnosis. Categorical variables are expressed as frequencies and percentages, and continuous variables as median and interquartile ranges
| Primary Causes | Secondary Causes | Under investigation |
p-value (Primary vs Secondary) |
||||
|---|---|---|---|---|---|---|---|
| Metabolic myopathy | Muscular dystrophy | Inflammatory myopathy | Neurogenic | ||||
| n = 18 | n = 7 | n = 4 | n = 2 | n = 62 | n = 27 | ||
| Sex (male) | 9 (50.0) | 4 (57.1) | 2 (50.0) | 1 (50.0) | 48 (77.4) | 27 (100.0) | 0.019 |
| Age (years) | 14 (11) | 4 (6) | 5 (8) | 4 (-) | 10 (10) | 15 (9) | 0.587 |
| Muscle weakness | 4 (22.2) | 6 (85.7) | 3 (75.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | < 0.001 |
| Exercise intolerance | 12 (66.7) | 2 (28.6) | 1 (25.0) | 0 (0.0) | 0 (0.0) | 0 (0.0 | < 0.001 |
| Peak CK (UI/L) | 7984 (75,980) | 3356 (10,638) | 2999 (5262) | 3911 (-) | 3674 (188,527) | 5089 (19,082) | 0.171 |
| Persistent hyperCKemia | 11 (61.1%) | 7 (100.0%) | 1 (25.0%) | 0 (0.0%) | 5 (8.1%) | 9 (33.3%) | < 0.001 |
| Recurrent hyperCKemia | 6 (33.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 17 (27.4%) | 7 (25.9%) | 0.447 |
| Rhabdomyolysis | 15 (83.3%) | 6 (85.7%) | 3 (75.0%) | 1 (50.0%) | 49 (79.0%) | 21 (77.8%) | 0.783 |
| Macroscopic hematuria | 7 (38.9%) | 3 (42.9%) | 1 (25.0%) | 0 (0.0%) | 8 (12.9%) | 9 (33.3%) | 0.008 |
| Kidney injury | 1 (5.6%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 4 (6.5%) | 0 (0.0%) | 0.536 |