TABLE 1.
Sheep used in this study
| Sheep | Breeda (age [mo])b | PrP genotypec | Symptom(s) |
|---|---|---|---|
| With scrapie | |||
| Sporadic | |||
| KH2 | S (48) | MARQ/MARR | NAd |
| KU | S (52) | MARQ/TARQ | Ataxia, subtle loss of fleece |
| SB | S (34) | MARQ/MARQ | Ataxia, debilitation |
| Y2 | S (35) | MARQ/MARQ | Ataxia, debilitation |
| Y5 | S (41) | MARQ/MARQ | Ataxia, debilitation |
| Endemic | |||
| S1 | S × C (12) | MARQ/MARH | Ataxia, hypersensitivity |
| S2 | S × C (21) | MARQ/MARH | Ataxia, hypersensitivity |
| S3 | S × C (16) | MARQ/MVRQ | Ataxia, hypersensitivity |
| Exptl | |||
| A1 | S (27) | MARQ/MARQ | Ataxia |
| B3 | S (21) | MARQ/TARQ | Ataxia |
| G1 | S (26) | MARQ/MARQ | Ataxia, debilitation |
| Healthy (S4) | S × C (20) | MARQ/MARQ |
a
Abbreviations: S, Suffolk; C, Corriedale; S × C, F1 of Suffolk and Corriedale.
b
Age of the sheep with scrapie grouped as sporadic or endemic indicates the age at death (months old), while that of the experimental group indicates time to death after inoculation (months postinoculation).
c
The nomenclature of PrP genotypes was described elsewhere (18).
d
NA, no record of clinical symptoms was available.