TABLE 1.
Effect of LPS O-antigen type of noncapsulated K. pneumoniae strains on survival in the lungs of micea
| O antigen | Strain | Log10 CFU per mouse (mean ± SD) |
|---|---|---|
| O1 | K2/n | 2.66 ± 0.1b |
| K21a/n | 3.6 ± 0.1b | |
| KP79 | 1.36 ± 0.4 | |
| KP82 | 3.2 ± 0.1b | |
| KP85 | 3.16 ± 0.3b | |
| O3 | K50/n | 1.5 ± 0.1b |
| K55/n | 1.7 ± 0.02b | |
| KP91 | 0.8b | |
| KP94 | 0.8 ± 0.7b | |
| KP88 | 0.8b |
a
Normal BALB/c mice were inoculated with 4 × 104 CFU/mouse of five O1-antigen-bearing Klebsiella strains (K2/n, K21a/n, KP79, KP82, KP85) and fiveO3-bearing Klebsiella strains (K50/n, K55/n, KP88, KP91, KP94). Mice were sacrificed 72 h after bacterial inoculation, the lungs were homogenized, and the CFU were counted. The results are the results of three different experiments (four animals per group).
b
Statistical differences (as determined by an ANOVA test) were found between O1 strains (K2/n, K21a/n, KP82, KP85) and each of the O3 strains (P < 0.013).