Table 4:

Metrics of Physical Function

Metric	Objective	Studied in inpatients	Associated with outcomes after liver transplantation	Additional comments
Karnofsky Performance Status	--	✓	✓	- Rapid, easy to administer - Strong evidence base to support its prognostic value both before and after transplant - Established cut-offs:  - High=80-100  - Medium=50-70  - Low=0-40
Clinical Frail Scale	--	--	--	- Rapid, easy to administer - Low granularity - Established cut-off for frail: CFS>4
Activities of Daily Living	--	✓	--	- Low ceiling effect
Fried Frailty Instrument	--	--	--	- Captures the multi-dimensional construct of frailty
6-minute walk test	✓	--	--	- Captures aerobic exercise capacity
Liver Frailty Index	✓	✓	✓	- Cirrhosis-specific metric - Strong evidence base to support its prognostic value both before and after transplant
Short Physical Performance Battery	✓	--	--	-
Cardiopulmonary Exercise Test	✓	--	✓	- Captures aerobic exercise capacity - Requires specialized equipment and personnel
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