TABLE 1.
Antigen dose regimen for the six immunization groupsa
| Dose or designation | Group 1 (Montanide) | Group 2 (Montanide) | Group 3 (aluminum hydroxide) | Group 4 (Montanide) | Group 5 (aluminum hydroxide) | Group 6 (Montanide) |
|---|---|---|---|---|---|---|
| Original protocol | ||||||
| Dose 1 (μg) | 10 | 30 | 30 | 100 | 100 | 300 |
| Dose 2 (μg) | 10 | 30 | 30 | 100 | 100 | 300 |
| Dose 3 (μg) | 10 | 30 | 30 | 100 | 100 | 300 |
| Final protocol | ||||||
| Dose 1 (μg) | 10 | 30 | 30 | 100 | 100 | 20 |
| Dose 2 (μg) | 10 | 30 | 30 | 10 | 10 | 20 |
| Dose 3 (μg) | 10 | 10 | 30 | 10 | 10 | 20 |
| Designation | M10-10-10 | M30-30-10 | A30-30-30 | M100-10-10 | A100-10-10 | M20-20-20 |
a
Each volunteer received three doses of peptide in association with Montanide ISA 720 (1 ml of a water-oil emulsion) or aluminum hydroxide (1 mg in suspension). The original immunization groups received an increasing dose regimen.