TABLE 3.

Incidence of local reactions associated with vaccines after each injection

Parameter	Group M10-10-10	Group M20-20-20	Group M30-30-10	Group M100-10-10	Group A30-30-30	Group A100-10-10	All groups
First injection
No.	6	6	6	5	6	6	35
No. with no symptoms	2	4	1	0	3	1	11
No. with pain	2	1	0	4	1	1	9
No. with functional limitation	0	0	0	0	0	0	0
No. with rednessa	1 (0)	1 (0)	0 (0)	1 (0)	3 (0)	1 (0)	7 (0)
No. with indurationb	1 (0)	2 (0)	3 (0)	3 (0)	1 (0)	1 (0)	11 (0)
No. with local heat	1	1	0	2	0	1	5
No. withdrawnc	0	0	0	0	0	0	0
Second injection
No.	6	6	6	5	6	6	35
No. with no symptoms	1	1	1	0	1	4	8
No. with pain	4	5	5	3	1	1	19
No. with functional limitation	0	1	1	2	0	0	4
No. with rednessa	0 (0)	5 (1)	4 (0)	3 (0)	4 (0)	1 (0)	17 (1)
No. with indurationb	1	4 (1)	3 (2)	4 (2)	2 (0)	0 (0)	14 (5)
No. with local heat	2	2	3	4	0	1	12
No. withdrawnc	0	1	2	2	0	0	5
Third injection
No.	6	5	4	3	6	6	30
No. with no symptoms	2	2	1	1	0	3	9
No. with pain	4	0	2	1	3	3	13
No. with functional limitation	1	0	0	0	1	0	2
No. with rednessa	3 (1)	3 (0)	3 (0)	1 (0)	5 (1)	2 (0)	17 (2)
No. with indurationb	2 (1)	2	2 (0)	0 (0)	4 (1)	0 (0)	10 (2)
No. with local heat	2	1	2	0	4	0	9

^aThe numbers in parentheses are the numbers of volunteers who had redness that was ≥10 cm in diameter.

^bThe numbers in parentheses are the numbers of volunteers who had indurations that were ≥5 cm in diameter.

^cNumber of volunteers who did not receive further injections because of unacceptable local reactions.