TABLE 4.

GM IgG anti-CP and anti-rSEC levels elicited in mice by the bivalent conjugate^a

Antibody	GM (EU)
	First injection	Second injection	Third injection
Anti-GAMP	<0.2	33.2	39.7
Anti-W135P	<0.2	2.5	8.5
Anti-rSEC	<0.2	5.5	45.7

^aThe bivalent conjugate was composed with GAMP-rSEC3 and W135P(H)-rSEC6 to a final concentration of 25 μg/ml of each CP; each mouse was immunized 0.1 ml. IgG responses in the second and third injections had statistic difference with the corresponding first injections (P < 0.01). Also, for 8.5 versus 2.5 and 45.7 versus 5.5, P < 0.05.