FIG. 6.

M. tuberculosis infection does not protect BALB/c mice against infection with P. yoelii 17XL. Two weeks after being infected via aerosol with low-dose M. tuberculosis CDC1551, mice were infected intraperitoneally with 10⁵ P. yoelii 17XL (Py17XL)-parasitized erythrocytes. Control BALB/c and C57BL/6 mice were infected with P. yoelii 17XL only. (A) Mortality 14 days after mice were infected with P. yoelii 17XL was significantly higher in BALB/c (diamonds) mice than in C57BL/6 (triangles) mice (P = 0.001). (B) Parasitemia in coinfected BALB/c mice (Mtb & Py17XL, circles) and mice infected with P. yoelii 17XL (squares) was greater than 80% by day 7 in both groups. (C) By day 10, 100% mortality was observed in both groups. The data shown is representative of two experiments with 10 mice included in each group. Bars represent the means ± the standard errors of the means.