TABLE 2.
Protection against B. melitensis infection induced by rOmp31 immunization is mediated by CD4+ T cells
| Vaccine (n = 8) | Treatment | Log10aB. melitensis organisms in spleen | Log units of protection |
|---|---|---|---|
| PBS | None | 5.43 ± 0.50 | |
| rOmp31 | None | 4.20 ± 0.40c | 1.23 |
| rOmp31 | Anti-CD4− | 5.06 ± 0.51d | 0.37 |
| rOmp31 | Anti-CD8− | 4.30 ± 0.21b | 1.13 |
| rOmp31 | IgG | 4.22 ± 0.60c | 1.21 |
| H38 | None | 3.11 ± 0.40c | 2.32 |
a
The content of bacteria in spleens is represented as the mean log CFU ± SD per group.
b
Significantly different from PBS-immunized mice (P < 0.05) as estimated by Dunnett's test.
c
Significantly different from PBS-immunized mice (P < 0.01) as estimated by Dunnett's test.
d
Significantly different from rOmp31-immunized mice (P < 0.05) as estimated by Dunnett's test.