TABLE 5.
Genes negatively regulated by Fur but independent of iron
| ORFa | Gene | Function | fur/WTb | Low iron/high ironc |
|---|---|---|---|---|
| VC0788 | DOPA dioxygenase related, COG3805 | 2.8 | 1.0 | |
| VC1048 | Hypothetical, COG0778 | 2.4 | 1.8 | |
| VC1461 | cep | Colonization factor | 2.1 | 1.3 |
| VC1562 | β-Lactamase-related protein, zinc hydrolase family, COG0491 | 21.6 | 1.2 | |
| VCA0538 | Putative cytochrome b561, COG3038 | 2.1 | 1.3 | |
| VCA0734 | Hypothetical | 2.9 | 0.99 | |
| VCA0969 | Pirin-related protein, cupin family of iron binding proteins, COG1741 | 3.8 | 0.99 |
a
ORF designation from TIGR database (33).
b
Mean expression ratio of the fur mutant relative to wild-type parental strain O395.
c
Mean expression ratio of the wild-type strain O395 grown in the absence relative to the presence of iron supplementation.