Table 2.
Median (IQR) responses by region
| Response Frequency, Median (IQR) | Total | ||||||
|---|---|---|---|---|---|---|---|
| Common-wealth (n = 6) | Western Europe (n = 7) | Central/Eastern Europe (n = 9) | Asia (n = 11) | Latin America (n = 7) | Middle-East/Africa (n = 5) | ||
| Utility Instrument (UI) use frequency | |||||||
| Total responses (N) | 33 | 27 | 22 | 83 | 33 | 13 | 211 |
| AQOL | 1 (0) | 1 (0) | 1 (1.0) | 1 (1.5) | 1 (1.5) | 1 (0.5) | 6.0 |
| EQ-5D | 4 (0) | 4 (0) | 4 (0) | 4 (0) | 3.5 (1.0) | 4 (0.5) | 23.5 |
| EQ-5D-Y | 1.75 (0.5) | 1 (1) | 2 (1.5) | 2 (1.0) | 2 (1.0) | 2 (0.5) | 10.75 |
| EQ-HWB | 1 (0) | 1 (0) | 1 (0.75) | 1 (0) | 1 (1.0) | 1 (0.5) | 6.0 |
| Bolt-ons | 1 (0) | 1 (0) | 1 (0.25) | 1 (0) | 1 (0) | 1 (0) | 6.0 |
| HUI | 2 (0.5) | 1 (1.0) | 1 (1) | 1.5 (1.0) | 1 (0) | 2 (0.5) | 8.5 |
| PROPR | 1 (0) | 1 (0) | 1 (0) | 1 (0) | 1 (0) | 1 (0.5) | 6.0 |
| QWB | 1 (0) | 1 (0) | 1 (0.5) | 1 (0) | 1 (0) | 1 (0) | 6.0 |
| SF-6D | 2 (0) | 2 (1.0) | 2 (1.0) | 2 (1.0) | 3 (1.0) | 2.5 (1.0) | 13.5 |
| UI used matters, n(%) | |||||||
| Yes | 31 (91.2) | 28 (90.3) | 22 (88.0) | 83 (88.3) | 33 (89.2) | 10 (66.7) | 207 (87.7) |
| No/ not sure | 3 (8.8) | 3 (9.7) | 3 (12.0) | 11 (11.7) | 4 (10.8) | 5 (33.3) | 29 (12.3) |
| Elicitation Method (EM) use frequency | |||||||
| Total responses (N) | 33 | 27 | 21 | 78 | 32 | 11 | 202 |
| BWS | 1 (0) | 1 (0) | 1.5 (2.0) | 1 (1.0) | 1.5 (1.0) | 2 (0.5) | 8.0 |
| DCE | 2 (0.5) | 1.5 (1.0) | 2 (1.0) | 2 (1.5) | 2 (1.0) | 3.5 (1.75) | 13.0 |
| PTO | 1.25 (1.0) | 1 (1.0) | 2 (0.5) | 2 (2.0) | 2 (0.5) | 2 (1.0) | 10.25 |
| SG | 2.25 (1.0) | 2 (1.0) | 2.75 (1.5) | 3 (1.0) | 3 (1.0) | 3.5 (1.5) | 16.5 |
| TTO | 4 (1.0) | 3.5 (1.0) | 3 (1.0) | 3 (1.0) | 3 (1.0) | 3.5 (1.0) | 20.0 |
| VAS | 2 (1.0) | 2 (1.0) | 3 (1.5) | 3 (1.5) | 3 (1.5) | 3.5 (1.0) | 16.5 |
| EM used matters, n (%) | |||||||
| Yes | 27 (79.4) | 26 (86.7) | 16 (69.6) | 71 (81.6) | 27 (75.0) | 11 (84.6) | 178 (79.8) |
| No/ not sure | 7 (20.6) | 4 (13.3) | 7 (30.4) | 16 (18.4) | 9 (25.0) | 2 (15.4) | 45 (20.2) |
| Health Preference Source (HPS) use frequency | |||||||
| Total responses (N) | 33 | 27 | 22 | 84 | 34 | 13 | 213 |
| General population own | 3.25 (2.0) | 3 (2.0) | 2 (1.0) | 3 (1.5) | 2 (0.5) | 1 (1.0) | 14.25 |
| General population other | 2.5 (1.0) | 2 (2.0) | 4 (1.0) | 3 (1.0) | 3 (1.0) | 3 (1.5) | 17.5 |
| Patient own | 2 (0) | 2 (1.0) | 1 (1.0) | 3 (1.0) | 2 (1.0) | 1 (1.0) | 11.0 |
| Patient other | 2 (2.0) | 2 (0.5) | 3 (1.5) | 2 (1.0) | 3 (1.0) | 3 (1.5) | 15.0 |
| HPS used matter, n (%) | |||||||
| Yes | 30 (88.2) | 30 (96.8) | 23 (92.0) | 86 (90.5) | 35 (92.1) | 13 (86.7) | 217 (91.2) |
| No/ not sure | 4 (11.8) | 1 (3.2) | 2 (8.0) | 9 (9.5) | 3 (7.9) | 2 (13.3) | 21(8.9) |
| Data quality issue frequency | |||||||
| Total responses (N) | 34 | 31 | 25 | 95 | 38 | 15 | 238 |
| Patient samples | 3 (2.0) | 3 (1.5) | 2 (0) | 3 (1.0) | 3 (2.0) | 2.5 (1.0) | 16.5 |
| Health states | 3 (1.0) | 2 (1.5) | 2 (1.0) | 3 (0) | 4 (1.0) | 3 (1.0) | 17.0 |
| Sample size | 3 (0.5) | 2 (1.0) | 3 (1.0) | 3 (0) | 3 (1.0) | 2 (1.0) | 16.0 |
| Old data | 2 (0) | 2 (0.5) | 2 (1.25) | 2 (1.0) | 2 (2.0) | 2.5 (0.5) | 12.5 |
| Different methods | 2.75 (1.0) | 2 (1.0) | 3 (1.0) | 3 (1.0) | 3 (2.0) | 3 (1.5) | 16.75 |
Abbreviations: Responses: 1: Never/not sure; 2: Occasionally; 3: Often; 4: Very often; Elicitation Methods: BWS: best-worst scaling; DCE: discrete choice experiment; PTO: person trade-off; SG: standard gamble; TTO: time trade-off; VAS: visual analogue scale; Health preference source: Refers to general population/ patients of one’s own country or other country; Data quality issue: Patient samples: The patient samples from which HRQoL/utility data was collected were inappropriate (e.g. poor representativeness); Health states: The health states (e.g. the vignettes) for which utility data was available do not match the health states in the CEA model; Sample size: The population samples from which HRQoL/utility data was collected were too small; Old data: The HRQoL/utility data was too old; Different methods: The utility values of different health states used in the same model were derived using different methods/instruments.
Countries in each region: Asia (China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, Thailand, Vietnam), Central/Eastern Europe (Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Poland, Romania, Slovenia), Western Europe (Austria, Denmark, Italy, Netherlands, Portugal, Spain, Sweden), Latin America (Argentina, Brazil, Chile Colombia, Ecuador, Mexico, Peru), Middle East/ Africa (Egypt, Saudi Arabia, South Africa, Tunisia, UAE), Commonwealth (Australia, Canada, England, New Zealand, Scotland, Wales).