TABLE 4.

Azole MFCs and MICs for 15 Aspergillus isolates in three laboratories

Medium and species (no. of isolates)a	Parameter	Range (MFC90s, MIC90s, or modal values)b
		Itraconazole	Voriconazole	Posaconazole	Ravuconazole
RPMI medium
A. fumigatus I-Suscep. (6)	MFC	0.2-4 (4)	0.5-4 (4)	0.06-2 (1)	0.5-4 (4)
	MIC	0.12-1 (1)	0.5-1 (1)	0.03-0.5 (0.2)	0.12-1 (1)
I-Res. (1 [isolate no. 5])	MFC	>8	1-2	1-2	2-4
	MIC	8->8	1	0.2-1	2
I-Res. (1 [isolate no. 6])	MFC	NDc	0.5-2	2->8	2
	MIC	>8	0.2-0.5	0.5-1	0.2
V-Res. (1)	MFC	1-4	2-8	0.2-0.5	4-8
	MIC	0.5-4	2-8	0.2	2-8
A. flavus (3)	MFC	0.12-1 (0.5)	0.5-2 (1)	0.06-0.5 (0.12)	1-4 (2)
	MIC	0.12-0.5 (0.2)	0.12-1 (1)	0.03-0.5 (0.06)	0.5-2 (2)
A. terreus (1)	MFC	0.5-4	2-4	0.2-1	4-8
	MIC	0.12-0.5	0.5-1	0.03-0.5 (0.03)	0.5-1
A. terreus (2)	MFC	0.2-1 (0.5)	1-4 (2)	0.12-0.2 (0.12)	1-4 (4)
	MIC	0.06-0.5 (0.2)	0.5-1 (0.5)	0.03-0.2 (0.03)	0.12-1 (0.5)
M3 medium
A. fumigatus I-Suscep. (6)	MFC	0.5-1 (1)	0.5-8 (4)	0.06-1 (0.5)	1-4 (4)
	MIC	0.2-1 (0.5)	0.5-4 (2)	0.03-0.12 (0.12)	0.5-2 (2)
I-Res. (isolate no. 5)	MFC	>8	2-4	0.5-2	>8
	MIC	8->8	1	0.2-1	>8
I-Res. (isolate no. 6)	MFC	>8	0.2-0.5	0.5-2	0.5-2
	MIC	4->8	0.2-0.5	0.5-1	0.2-0.5
V-Res. (1)	MFC	2->8	8->8	0.2-0.5	8->8
	MIC	2->8	8->8	0.2-0.5	8->8
A. flavus (3)	MFC	0.12-0.5 (0.5)	2-4 (4)	0.06-0.5 (0.12)	1-4 (2)
	MIC	0.12-0.5 (0.5)	0.5-4 (2)	0.12-0.2 (0.12)	0.5-4 (2)
A. terreus (1)	MFC	1-2	4-8	0.2-0.5	4-8
	MIC	0.2-1	2-4	0.12-0.2	1-2
A. terreus (2)	MFC	0.5-1 (0.5)	4-8 (4)	0.12-0.5 (0.2)	2-8 (4)
	MIC	0.06-0.5 (0.5)	1-4 (2)	0.03-0.2 (0.2)	0.2-2 (1)

^aI-Suscep, itraconazole-susceptible isolates; I-Res., itraconazole-resistant isolates; V-Res., voriconazole-resistant laboratory mutant.

^bMFC₉₀s, MIC₉₀s for six isolates; modal values for three isolates.

^cND, not determined.