Fig. 1.

The effects of fast 20-s infusion of IV SNC80 on convulsive (a) and antidepressant-like effects in the forced swim test (b) in Sprague–Dawley rats (N=6 per dose). Drug was injected 30 min prior to the forced swim test. The bars and vertical lines above each bar represent the mean and standard error of the mean (SEM) for immobility (open bars), swimming counts (single-hatched bars), and climbing counts (double-hatched bars). * indicates p<0.05, and ** indicates p<0.01, as compared to vehicle as determined by Dunnett’s post hoc test