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Brain equivalents of the delta-opioid agonist SNC80 or its delta-opioid metabolite measured 30 min following the termination of a 20-s, 20-min, or 60-min infusion of 1.0, 3.2, or 10 mg kg−1 IV SNC80
| Infusion duration | Dose (mg kg−1) | Average brain equivalents (nM) (±SEM) |
|---|---|---|
| 20 s | 1 | 1.86 (0.71) |
| 3.2 | 12.1 (6.46) | |
| 10 | >100 | |
| 20 min | 1 | 0.87 (0.36) |
| 3.2 | 11.73 (0.87) | |
| 10 | >100 | |
| 60 min | 1 | <0.1 |
| 3.2 | 4.76 (1.56) | |
| 10 | 11.23 (2.36) |
