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The effects of a SNC80 pretreatment (s.c.) 1 h prior to dose threshold determination for SNC80-induced convulsions
| SNC80 pretreatment | Number of convulsing rats per group | Average dose infused (mg kg−1) | Convulsive dose (mg kg−1) |
|---|---|---|---|
| Vehicle | 6/6 | 3.11 (0.19) | 3.11 (0.19) |
| 0.1 | 5/6 | 7.80 (4.44) | 3.36 (0.16) |
| 0.32 | 4/6 | 12.47 (5.55) | 3.70 (0.81) |
| 1.0 | 4/6 | 13.20 (5.32) | 4.80 (0.47) |
| 3.2 | 2/6 | 21.45 (5.41) | 4.36 (0.43) |
| 10 | 0/6 | 30 | N/A |
