a, time course of effects of SNC80 on locomotor activity in Sprague-Dawley rats (n = 6 per dose) after an acute injection of vehicle, 3.2, 10, or 32 mg/kg. Locomotor activity counts before time 0 were baseline levels of activity before the injection (subcutaneously) that occurred at time 0. b, effects of repeated administration of SNC80 on locomotor activity in Sprague-Dawley rats. Data are represented as positive area under curve relative to averaged vehicle activity counts for each day, and statistical analysis is compared across subsequent days of injections for a single dose of SNC80 by one-way ANOVA with Tukey’s post hoc test.***, p < 0.001 as compared with all subsequent days of injections with either 10 or 32 mg/kg SNC80 by post hoc comparison. *, p < 0.05 as compared with days 2, 3, 5, and 6 of 3.2 mg/kg SNC80 by post hoc comparison; #, p < 0.001 as compared with day 4 with 3.2 mg/kg SNC80 by post hoc comparison and p < 0.01 as compared with day 7 with 3.2 mg/kg SNC80 by post hoc comparison.