The effects of SNC80 in the forced swim test after acute (a), 2 (b), 3 (c), or 7 (d) days of drug administration in Sprague-Dawley rats (n = 6 per dose). Drug was injected 60 min before the forced swim test. The bars and vertical lines above each bar represent the mean and S.E.M. for immobility (open bars), swimming counts (single-hatched bars), and climbing counts (double-hatched bars). *, p < 0.05;**, p < 0.01 as compared with vehicle only as determined by Dunnett’s post hoc test.