The effects of increasing doses of SNC80 on convulsions (a) and antidepressant-like effects (b) in Sprague-Dawley rats (n = 6 per dose). Either vehicle or one dose of SNC80 was injected once daily; 60 min after the final injection, rats were evaluated in the forced swim test. The bars and vertical lines above each bar represent the mean ± S.E.M. for immobility (open bars), swimming counts (single-hatched bars), and climbing counts (double-hatched bars). *, p < 0.05; **, p < 0.01;***, p < 0.001 as compared with vehicle only as determined by Dunnett’s post hoc test.