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. Author manuscript; available in PMC: 2005 Dec 6.
Published in final edited form as: J Nutr. 2005 Jan;135(1):42–47. doi: 10.1093/jn/135.1.42

TABLE 3.

Effect of biotin deficiency on expression of biotin-related genes in human leukocytes

Gene d 01 d 281 d 28/d 02 P3
MCCA 25 20 0.80 (0.67,0.95) 0.029
MCCB 20 16 0.82 (0.65,1.03) 0.093
PCCA 25 19 0.76 (0.61,0.94) 0.027
PCCB 20 17 0.86 (0.75,1.00) 0.067
PC 14 12 0.82 (0.74,0.91) 0.004
ACCA 18 14 0.78 (0.67,0.91) 0.011
ACCB 46 38 0.82 (0.69,0.97) 0.040
HCS 17 14 0.82 (0.69,0.97) 0.038
Biotinidase 23 18 0.79 (0.65,0.96) 0.037
SMVT 20 16 0.77 (0.64,0.93) 0.019
SLC19A3 203 68 0.33 (0.16,0.70) 0.016
1

Values are the means of gene expression determined as geometrical averages of RT-PCR data for 7 subjects.

2

Values are ratios of gene expression of d 28 to d 0 and the corresponding 95% CI (shown in parentheses). To calculate the ratio, RT-PCR data were log transformed and the difference between d 28 and d 0 was determined for each of 7 subjects; the mean of 7 differences was then calculated for each gene and this mean was reverse transformed to obtain the ratio of gene expression. The corresponding 95% CI was determined in the log scale and its low and high values were then reverse transformed.

3

Significance of the differences between the log-transformed data at d 28 and d 0 was tested by two-tailed, paired t test; values represent P-values for each gene.