Figure 2.

Elucidation of KLF2-regulated global gene expression programs. (A) Visualization of whole-genome expression patterns controlled by KLF2 and/or IL-1β in HUVECs. HUVECs were infected with either Ad-GFP or Ad-KLF2 and incubated for 24 hours before RNA was isolated and analyzed using whole genome microarrays. Self-organizing map software was used to cluster similarly regulated genes and colorize them based on intensity of expression relative to GFP-expressing (control) cells. (B) Selected KLF2-responsive genes grouped by clusters shown in A, with major associated biological functions listed. Dev, development.