Figure 3.

Sequence alignement of human Arf and Arf family proteins. Ran is included to stress the short interswitch of Arf family proteins. Subfamily-distinguishing features detailed in Table I are highlighted in green, interswitch toggle determinants in red. Accession numbers are provided in Supplementary table 3. Alignments were performed with Clustal_W (http://npsa-pbil.ibcp.fr/) and shaded with Boxshade (http://www.ch.embnet.org/software/BOX_form.html). Interspecies alignments are provided in Supplementary figure 4.