Table 1.
Some of the viruses and immune evasion strategies discussed in this report
| Virus | Family (genome) | Protein | Function/mechanism |
| Vaccinia virus (VV) | Poxvirus (DNA) | Interleukin 18 (IL-18) binding protein (IL-18BP) | Secreted protein that binds IL-18 and neutralizes its activity |
| Molluscum contagiosum virus (MCV) | Poxvirus (DNA) | IL-18BP | Secreted protein that binds IL-18 and neutralizes its activity |
| Ectromelia virus (EV) | Poxvirus (DNA) | CD30 | Secreted protein that binds CD30 ligand |
| Fowlpox virus (FPV) | Poxvirus (DNA) | Interferon-γ (IFN-γ) receptor | Secreted protein that binds IFN-γ, unrelated to host receptor |
| Yaba-like disease virus (YLDV) | Poxvirus (DNA) | Viral chemokine receptors (vCKRs) | Membrane protein that binds chemokines |
| Human cytomegalovirus (HCMV) | Herpesvirus (DNA) | US28 | vCKR |
| US27, UL33 | vCKR homologues | ||
| US2, US11 | Degrade MHC class I molecules | ||
| US3, US10 | Interference with MHC class II presentation | ||
| Upregulation of CD95L and TRAIL and induction of apoptosis in T cells | |||
| Murine cytomegalovirus (MCMV) | Herpesvirus (DNA) | Viral chemokine (vCK) | Chemoattractant properties |
| M04, M06 | Downregulation of MHC class I | ||
| M152 | Interferes with MHC class I presentation and NK cell activation | ||
| Kaposi's sarcoma-associated herpesvirus (KSHV) | Herpesvirus (DNA) | vCKR ORF74 | Membrane protein that binds chemokines, consitutively activated, implicated in the development of Kaposi's sarcoma lesions |
| Murine γ-herpesvirus 68 (MHV-68) | Herpesvirus (DNA) | Viral chemokine binding protein (vCKBP) M3 | Secreted, binds and neutralizes chemokines |
| α-herpesviruses | Herpesvirus (DNA) | vCKBP | Secreted, binds and neutralizes chemokines |