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Absorption of AHT-102 in hCD3EDG mice. Mean plasma concentration–time curves (mean ± SD, n = 12) following a single intravenous injection of 0.1-mg/kg, 0.5-mg/kg, and 2.5-mg/kg doses of AHT-102 in human CD3EDG transgenic mice. Blood samples were collected at 11 specific time points: pre-dose (0 min), 2 min, 15 min, 30 min, 45 min, 1 h, 2 h, 4 h, 8 h, 12 h, and 24 h post-dose
