Table 1.

Pharmacokinetic parameters of different doses of AHT-102 after a single intravenous injection in hCD3EDG mice

Parameters	Unit	AHT-102 (0.1 mg/kg)	AHT-102 (0.5 mg/kg)	AHT-102 (2.5 mg/kg)
Kel	1/h	0.910	0.228	0.111
t½	h	0.762	3.05	4.25
Tmax	h	0.0333	0.0333	0.0333
Cmax	ng/mL	2330	11,100	58,400
AUC(0–t)	h*ng/mL	1210	6270	31,900
AUCinf	h*ng/mL	1220	6330	32,000
AUCextr	%	1.45	0.958	0.391
Vd	mL/kg	89.9	347	705
CL	mL/h/kg	81.8	79.0	78.2
MRTinf	h	0.676	1.01	1.04

AUC_(0–t) area under the plasma concentration–time curve from zero to the time of the last quantifiable concentration, AUC_extr percentage of AUC extrapolated from the last measurable concentration to infinity, AUC_inf AUC from time zero to infinity, CL total body clearance, C_max maximum plasma concentration, Kel terminal elimination rate constant, MRT_inf mean residence time from time zero to infinity, t_½ terminal half-life, T_max time to C_max, V_d volume of distribution.