Table 3.

Blood biochemistry parameters (mean ± SD) following 5-week repeated intravenous administration of AHT-102 in hCD3EDG mice on day 1 of the recovery period

Parameters	Unit	Sex	Test date	Vehicle	AHT-102 (1.5 mg/kg)	AHT-102 (4.5 mg/kg)	AHT-102 (13.65 mg/kg)
ALB	g/L	Female	R1	36.3 ± 1.42	35.4 ± 1.15	34.1 ± 0.94**	33.9 ± 1.23**
TP	g/L	Female	R1	42.8 ± 1.65	41.9 ± 1.36	40.2 ± 0.97**	40.0 ± 1.95**
ALB	g/L	Male	R1	40.2 ± 1.45	38.1 ± 1.70	37.5 ± 3.07*	37.9 ± 1.04*
A/G		Male	R1	3.85 ± 0.313	3.32 ± 0.241**	3.64 ± 1.767*	3.23 ± 0.226**

R recovery phase, n = 10

A/G albumin/globulin ALB normal albumin, TP total protein

*Indicating statistical significance compared with vehicle control group of p < 0.05

**Indicating statistical significance compared with vehicle control group of p < 0.01