Table 4.

Univariate and multivariate analyses of various clinical variables in colorectal cancer patients based on OS

Clinical variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	$P$ value	HR (95%CI)	$P$ value
Age ($⩽$ 65 vs. $>$ 60 years)	0.633(0.302–1.329)	0.227	1.751(0.728–4.215)	0.211
Gender (Male vs. Famale)	0.772(0.366–1.627)	0.497	2.031(0.836–4.934)	0.188
Differentiation (High $+$ Moderate vs. Low)	2.327(1.071–5.054)	0.033	0.336(0.140–0.958)	0.041
Tumor size ($⩽$ 5 vs. $>$ 5cm)	0.236(0.211–1.468)	0.236	1.637(0.613–4.376)	0.326
T stage (T1–2 vs. T3–4)	7.894(1.039–59.96)	0.046	0.271(0.028–2.611)	0.258
N stage (N0 vs. N1–2)	3.272(1.478–7.242)	0.003	30.76(1.982–477.6)	0.014
M stage (M0 vs. M1)	10.41(3.882–27.90)	0.001	0.138(0.036–0.529)	0.004
Clinical stage (I $+$ II vs. III $+$ IV)	3.859(1.695–8.786)	0.001	0.017(0.001–0.281)	0.004
CEA (N vs. P)	3.013(1.418–6.404)	0.004	0.300(0.133–0.674)	0.004
CA19-9 (N vs. P)	2.027(0.890–4.619)	0.093	0.581(0.229–1.473)	0.253
CA72-4 (N vs. P)	2.942(1.365–6.342)	0.006	0.649(0.264–1.596)	0.346
Serum MR (Low vs. High)	2.662(1.174–6.035)	0.019	0.840(0.335–2.105)	0.711
Serum CD163 (Low vs. High)	6.268(1.893–20.75)	0.003	0.194(0.053–0.708)	0.013

Note: HR, hazard ratio. 95%CI, 95% confidence interval. N, negative. P, positive.