Table 2.

Summary of ROC analysis results for RNASE1, RAC score, C3, C4, and proteinuria in stratifying disease activity levels in patients with SLE.

Comparison	AUC (95%CI)	Cut-off	Sensitivity (100%)	Specificity (100%)	PPV	NPV	Youden's index	P-value
RNASE1
SLE vs HC	0.7789 (0.7196-0.8383)	31.84	60.00	92.11	93.55	54.69	0.5211	<0.0001
RNASE1
≥mild activity	0.6805 (0.5787-0.7823)	31.59	70.09	65.79	85.23	43.86	0.3588	0.0010
≥moderate activity	0.6423 (0.5524-0.7321)	29.03	86.57	43.59	56.86	79.07	0.3016	0.0032
≥severe activity	0.6634 (0.5646-0.7621)	34.88	77.78	55.93	28.77	91.67	0.3371	0.0082
RAC score
≥mild activity	0.7753 (0.6973-0.8533)	10.39	50.96	94.29	96.36	39.29	0.4525	<0.0001
≥moderate activity	0.7793 (0.7006-0.8580)	10.25	61.54	86.49	80.00	71.91	0.4803	<0.0001
≥severe activity	0.8086 (0.7222-0.8950)	10.54	84.00	68.42	36.84	95.12	0.5242	<0.0001
C3
≥mild activity	0.7472 (0.6647-0.8297)	0.7950	58.88	81.58	90	41.33	0.4046	<0.0001
≥moderate activity	0.6682 (0.5784-0.7579)	0.8050	68.66	65.38	63.01	70.83	0.3404	0.0005
≥severe activity	0.8015 (0.7296-0.8733)	0.8050	96.30	60.17	35.62	98.61	0.5647	<0.0001
C4
≥mild activity	0.7511 (0.6723-0.8299)	0.1550	60.75	84.21	91.55	43.24	0.4496	<0.0001
≥moderate activity	0.6677 (0.5771-0.7583)	0.1250	61.19	71.79	65.08	68.29	0.3298	0.0005
≥severe activity	0.7859 (0.7056-0.8663)	0.1450	88.89	61.02	34.29	96.00	0.4991	<0.0001
Proteinuria
≥mild activity	0.7253 (0.6333-0.8174)	0.7680	49.00	93.10	96.08	34.62	0.4210	0.0002
≥moderate activity	0.7032 (0.6100-0.7965)	0.8925	55.74	85.29	77.27	68.24	0.4103	<0.0001
≥severe activity	0.6727 (0.5619-0.7835)	0.7680	66.67	67.65	35.29	88.46	0.3432	0.0059