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. 2026 Apr 1;17:1782968. doi: 10.3389/fphar.2026.1782968

FIGURE 2.

Panel A is a horizontal bar divided into three colored risk categories labeled low risk in green from zero to three, moderate risk in yellow from three to six, and high risk in red from six to ten. A dashed vertical line at 7.5 appears within the red region and is labeled high-risk zone. Panel B depicts a horizontal bar for logistic model probability values from zero to one, marking a threshold at zero point three to classify high-risk PARS, with the chosen threshold labeled and shown with a dashed line.

PARS rescaled strata and High-risk PARS decision rule for the primary drug-based logistic regression model (patient-level 80–20 split stratified by whether a patient had ≥ 1 High-risk PARS visit; all visits from a patient confined to a single split. (A) The continuous PARS rescaled score is mapped to qualitative bands on a 0–10 scale: low risk (0–3), moderate risk (3–6), and high risk (6–10). (B) Output of the drug-based logistic model shown as predicted probability of High-risk PARS (defined as PARS ≥τ 75); the vertical dashed line marks the pre-specified operating threshold of 0.30; visits with p^≥ 0.3 are labeled as screen-positive (predicted High-risk PARS = 1, otherwise 0.).