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. 2026 Apr 1;17:1782968. doi: 10.3389/fphar.2026.1782968

TABLE 4.

Comparative performance of three validation schemes for the High-risk PARS logistic classifier. Accuracy, precision, recall, and F1 are reported at the fixed clinical threshold of 0.30. Primary analysis uses patient-level 80–20 split stratified by High-risk status. Metrics for precision, recall, and F1 refer to the positive class (High-risk PARS = 1).

Model Split strategy AUC Accuracy Precision (1) Recall (1) F1 (1)
80–20, strat high-risk only Train/test 80–20 at patient level; stratified by patient indicator of having ≥ 1 high-risk PARS visit 0.931 0.908 0.795 0.808 0.802
80–20, strat age + sex + High-risk Train/test 80–20; combined stratification by age group ( < 65/ ≥ 65), sex (F/M), and high-risk PARS (yes/no) 0.938 0.878 0.754 0.781 0.767
5-Fold GroupKFold 5-Fold cross-validation grouped by patient (GroupKFold); all visits of a patient are confined to a single fold 0.939 0.883 0.749 0.818 0.781