Table 2.
Conventional LV structural measurements of HCM subgroups
| All (n=216) | HCM with Moderate Hypertrophy | p-value | |||
|---|---|---|---|---|---|
| Nonobstructive (n=38) |
Provokable LVOTO(n=63) | Resting LVOTO (n=115) |
ANOVA | ||
| Maximal WT, mm | 16 (15,17) | 16 (15,17) | 15 (14,16) | 16 (15,17)* | 0.009 |
| LVEDVI, ml/m2 | 49.7 (42.8,56.1) | 51.9 (41.7,59.4) | 54.2 (45.8,59.9) | 58.5 (48.94,64.0) | 0.030 |
| LVESVI, ml/m2 | 18.72 (16.1,20.5) | 18.2 (14.7,22.9)#* | 15.91 (12.35,20.05) | 15.12 (12.8,18.82) | <0.001 |
| LVEF, % | 66 (60,64) | 63.0 (57.8,62.5)# | 66.4 (63.1,73.9)# | 71.2(65.01,77.3)* | <0.001 |
| LAVI, ml/m2 | 38 (30,45.92) | 35 (26,41.75)# | 34.7 (28,39)# | 42 (34.2,50.95)* | <0.001 |
| E/e’ | 13 (10,16) | 10.8 (8,12.75)# | 12 (8.22,15)# | 15 (12,18)* | <0.001 |
| SAM | 2 (0,3) | 0 (0,1)# | 1 (0,2)# | 3 (2,4)* | <0.001 |
| 2D GLS, % | -15.99±3.12 | -13.95±3.54#* | -16.16±2.75# | -16.56±2.91 | <0.001 |
| MR grade | 2 (1,3) | 1 (1,1)# | 1 (1,2)# | 3 (2,4)* | <0.001 |
| Septal morphology | |||||
| Sigmoid | 137(63.4%) | 8(21.1%)#* | 46(73.0%)# | 83(62.6%)* | <0.001 |
| Reverse curve | 48(22.2%) | 20(52.6%)#* | 9(14.3%)# | 19(14.8%)* | <0.001 |
| Others | 31(14.4%) | 10(26.3%)# | 8(12.7%) | 13(4.3%) | <0.001 |
| CMR-derived LGE | 150(69.4%) | 19(50%) | 38(60.3%) | 93(80.9%) | |
| <5% | 126(84%) | 9/19(47.4%)#* | 31/38(81.6%) | 86/93(92.5%) | <0.001 |
| 5-15% | 19(12.7%) | 8/19(42.1%)#* | 4/38(10.5%)# | 7/93(0.8%)* | <0.001 |
| ≥15% | 5(3.3%) | 2/19(10.5%)#* | 3/38(7.9%) | 0 | <0.001 |
| SubMV Score | 1(0,1) | 1 (0,1)# | 1 (0,1)# | 1 (1,2)* | <0.001 |
| Accessory papillary muscle | 40 (18.52%) | 6 (15.79%) | 10 (15.87%) | 24 (20.87%) | 0.234 |
| Anterior displacement of papillary muscles | 77 (35.65%) | 11 (28.95%) | 14 (22.22%)# | 52 (45.22%)* | 0.006 |
| Papillary muscle hypertrophy | 12 (5.56%) | 2 (5.26%) | 3 (4.76%) | 7 (6.09%) | 0.931 |
| Papillary muscle multifurcation | 25 (11.63%) | 3 (7.89%) | 1 (1.61%)# | 21 (18.26%)* | 0.003 |
| Insertion of papillary muscle into the mitral leaflet | 6(2.8%) | 0(0) | 1(1.6%) | 5(4.3%) | 0.291 |
Footnote: Data are presented as mean ± standard deviation or median (interquartile range) for continuous variables and number (percentage) for categorical variables. Comparisons among groups were performed using one-way analysis of variance (ANOVA) or the Kruskal-Wallis test for continuous variables, and the chi-square test for categorical variables. Adjusted p-values were calculated using the Bonferroni correction for multiple comparisons. #indicates vs. resting LVOTO, * indicates vs. provokable LVOTO. WT: wall thickness, LVEDVI: left ventricular end diastolic volume index, LVESVI: left ventricular end systolic volume index, LVEF: left ventricular ejection fraction, LAVI: left atrial volume index, SAM: systolic anterior motion, GLS: global longitudinal strain, MR: mitral regurgitation, CMR: cardiac magnetic resonance, LGE: late gadolinium enhancement