TABLE 2.
Resistance to antituberculosis drugs of M. tuberculosis strains isolated from 119 patients in Archangels Oblast, Russia, in 1998 and 1999, according to genotype and clustering
| Resistance | Genotype
|
Clustering
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) of strains
|
OR (95% CI) | P | No. (%) of strains that were:
|
OR (95% CI) | P | ||||
| Total | Of the following genotype:
|
Clustered (n = 71) | Nonclustered (n = 48) | ||||||
| Beijing (n = 53) | Non-Beijing (n = 66) | ||||||||
| Ethambutol | 38 (31.9) | 22 (41.5) | 16 (24.2) | 2.2 (1.0-5.3) | 0.04 | 28 (39.4) | 10 (20.8) | 2.5 (1.0-6.3) | 0.03 |
| Isoniazid | 55 (46.2) | 33 (62.3) | 22 (33.3) | 3.3 (1.4-7.6) | 0.001 | 42 (59.2) | 13 (27.1) | 3.9 (1.6-9.4) | 0.001 |
| Rifampin | 30 (25.2) | 23 (43.4) | 7 (10.6) | 6.5 (2.3-19.0) | <0.001 | 27 (38.0) | 3 (6.3) | 9.2 (2.4-41.7) | <0.001 |
| Streptomycin | 56 (47.1) | 39 (73.6) | 17 (25.8) | 8.0 (3.3-20.2) | <0.001 | 45 (63.4) | 11 (22.9) | 5.8 (2.4-14.7) | <0.001 |
| Any one drug | 67 (56.3) | 41 (77.4) | 26 (39.4) | 5.3 (2.2-13.0) | <0.001 | 50 (70.4) | 17 (35.4) | 4.3 (1.8-10.4) | <0.001 |
| MDR | 30 (25.2) | 23 (43.4) | 7 (10.6) | 6.5 (2.3-19.0) | <0.001 | 27 (38.0) | 3 (6.3) | 9.2 (2.4-41.7) | <0.001 |