Table 2.

Clinical trials of drugs targeting amino acid metabolism

Drug Name	Target Amino Acid	Development Phase	Outcomes	Clinical Trial ID
Arginine hydrochloride	Arginine	PHASE3	Treatment of Advanced Hepatocellular Carcinoma	NCT03950518
S-adenosyl-L-methionine (SAMe)	Methionine	PHASE3	Treatment of Nonalcoholic Fatty Liver Disease	NCT01754714
Branch Chain Amino Acid	Branched-chain Amino Acids (Leucine, Isoleucine, Valine)	PHASE2	Supplementation for Hepatocellular Carcinoma	NCT03908255
Arginine hydrochloride	Arginine	PHASE3	Treatment of Intermediate-stage Hepatocellular Carcinoma	NCT03274427
DRP-104	Glutamine	PHASE1|PHASE2	Treatment of Advanced Stage Fibrolamellar Carcinoma	NCT06027086
Siliphos-Selenium-Methionine-Alpha Lipoic Acid	Methionine	PHASE4	Treatment of Fatty Liver and Non-alcoholic Steatohepatitis	NCT01650181
S-adenosylmethionine	Methionine	PHASE3	Therapy for Non-Alcoholic Steatohepatitis	NCT00108589