Table 2.

Substrate scope of bioactive molecules and dienophiles

^aAcid (2 equiv.), maleimide-fluorescein (1 equiv.) was added. ^bReaction conditions: HFIP (0.1 ml), xylene (1.0 ml), 4.0 equiv. LiCl, 160 °C, 18 h. ^cReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 2.0 equiv. NaH₂PO₄, 150 °C, 18 h. ^dReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 150 °C, 18 h. ^eReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 1.0 equiv. KH₂PO₄, acid 5 equiv., vinylphenylketone 1 equiv., 160 °C, 18 h. ^fReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), acid 5 equiv., methyl acrylate 1 equiv., Pd(OAc)₂ were used as catalysts, 160 °C, 18 h.