Table 2.
Characteristics of Oji-Cree type 2 diabetic patients according to MTHFR 677C>T genotype (max n = 138)
| N | 677C/C | 677C/T | P | |
| N (men/women) | 138 | 108 (41/67) | 30 (8/22) | NS (0.25) |
| Age (years) | 138 | 46.4 ± 11.1 | 45.1 ± 13.5 | NS (0.60) |
| BMI (kg/m2) | 137 | 29.7 ± 4.7 | 32.6 ± 5.5 | 0.0050 |
| Waist circumference (cm) | 137 | 103 ± 9 | 106 ± 11 | NS (0.063) |
| Current smoker (%) | 138 | 50.0 | 50.0 | NS (1.00) |
| Duration of diabetes (years) | 138 | 8.53 ± 6.35 | 9.20 ± 7.01 | NS (0.62) |
| Fasting glucose (mmol/L) | 130 | 10.20 ± 3.91 | 9.28 ± 3.03 | NS (0.33) |
| HbA1c (%) | 136 | 8.36 ± 2.25 | 8.66 ± 2.18 | NS (0.47) |
| Total cholesterol (mmol/L) | 133 | 4.91 ± 1.07 | 4.67 ± 0.82 | NS (0.27) |
| HDL-C (mmol/L) | 133 | 1.21 ± 0.29 | 1.21 ± 0.29 | NS (0.91) |
| LDL-C (mmol/L) | 130 | 2.75 ± 0.71 | 2.70 ± 0.67 | NS (0.78) |
| Plasma triglycerides (mmol/L) | 133 | 2.20 ± 2.78 | 1.66 ± 0.60 | NS (0.15) |
| Systolic BP (mmHg) | 138 | 123 ± 16 | 132 ± 22 | 0.021 |
| Diastolic BP (mmHg) | 138 | 73.9 ± 8.9 | 77.4 ± 9.4 | NS (0.077) |
| Hypertensive (%) | 138 | 62.0 | 66.7 | NS (0.64) |
| CRP (mg/L) | 133 | 4.91 ± 6.65 | 6.53 ± 8.37 | NS (0.19) |
| ABI, left | 138 | 1.08 ± 0.09 | 1.05 ± 0.12 | NS (0.26) |
| ABI, right | 138 | 1.08 ± 0.09 | 1.07 ± 0.13 | NS (0.73) |
Data are means ± s.d., unless otherwise indicated.
Hypertension: systolic BP ≥ 130 and/or diastolic BP ≥ 80 and/or antihypertensive treatment
Abbreviations: BMI, body mass index; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure; CRP, C-reactive protein; ABI, ankle-brachial index; NS, not significant.