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Dioxin-induced hepatocellular toxicity depends on AHR signaling in hepatocytes. Hepatocellular toxicity in dioxin-treated Ahrfx/fxCreAlb mice is attenuated compared with dioxin-treated Ahrfx/fx mice. Liver sections were stained with hematoxylin and eosin for assessment of liver pathology after dioxin treatment regimen. Black arrowhead, extensive hydropic vacuolation and degeneration in portal region; asterisk, granuloctye infiltration. (Magnification: ×20.)
