Table 2.

Toxicity results using ProTox – 3.0 Software. BBB: Blood Brain Barrier; LD50: Median Lethal Dose.

LIGANDS	LD50 Value (mg/kg)	Toxicity class	Hepatotoxicity	Neurotoxicity	Carcinogenicity	Immunotoxicity	Mutagenicity	Cytotoxicity	BBB-barrier
Levodopa	1460	4	Inactive	Inactive	Inactive	Inactive	Active	Inactive	Inactive
Nobiletin	5000	5	Inactive	Inactive	Inactive	Active	Inactive	Inactive	Active
Nevadensin	3919	5	Inactive	Inactive	Inactive	Active	Inactive	Inactive	Inactive
3,5,6,7,8-Pentamethoxyflavone	5000	5	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive	Active
Eupatilin	5000	5	Inactive	Inactive	Inactive	Active	Inactive	Inactive	Inactive
Butein	1000	4	Inactive	Inactive	Active	Active	Inactive	Inactive	Active
Norwogonin	3919	5	Inactive	Inactive	Active	Inactive	Active	Inactive	Active
Tricin	4000	5	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive
Wogonin	3919	5	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive	Active
17-DMAG	27	2	Inactive	Inactive	Inactive	Active	Inactive	Inactive	Inactive
5-Hydroxy-3,7,8,3′,4′-pentamethoxyflavone	5000	5	Inactive	Inactive	Inactive	Active	Inactive	Inactive	Active
6-Methoxytricin	1190	4	Active	Active	Inactive	Active	Inactive	Inactive	Inactive