Figure 2.

Co-methylation network analysis of depression or PTSD patients after physical injury. (A) Circular plot of the co-methylation network. The outermost track is chromosome bands of the whole genome, mapped by the genomic density of co-methylation regions in blue. The density plot of the identified co-methylation modules is shown in red. The DMRs were visualized with the inner track (depression and PTSD patients) and the outer track (depression patients) in beta value, which is the condition difference coefficient. The innermost track represents the mean methylation status of the co-methylation modules excluding the unassigned gray module for both patient groups. Hub regions were labeled and PCDHGB4, PCDHGA7, and PCDHA6 were also found within DMRs. (B) Bar plot showing the significant GO terms, including BP and MF. The CC category did not enrich any terms and is not shown. BP = biological process, DMRs = differentially methylated regions, GO = gene ontology, MF = molecular function, PTSD = post-traumatic stress disorder.