Table 1.
Two-sample mendelian randomization results of the top 10 correlations of the DNAm to depression or post-traumatic stress disorder.
| CpGs | Feature | Chr | Gene | SE | Beta (95% CI) | OR (95% CI) | P | FDR-P | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| cg12661624 | Body | 7 | PTPRN2 | 3.53E−02 | 0.15 (0.08–0.22) | 1.16 (1.09–1.25) | 1.91E−05 | 9.04E−03 | Depression |
| cg24526596 | 5′UTR | 8 | DLGAP2 | 1.67E−02 | −0.07 (−0.1 to −0.04) | 0.93 (0.9–0.96) | 3.87E−05 | 9.04E−03 | Depression |
| cg00157656 | Body | 8 | ERICH1 | 7.98E−02 | −0.32 (−0.48 to −0.17) | 0.72 (0.62–0.85) | 4.79E−05 | 9.60E−03 | Depression |
| cg12317217 | Body | 5 | PCDHA2 | 5.06E−02 | −0.19 (−0.29 to −0.09) | 0.83 (0.75–0.92) | 2.27E−04 | 3.97E−02 | Depression |
| cg23997185 | 1stExon | 5 | PCDHB2 | 7.50E−02 | 0.26 (0.12–0.41) | 1.3 (1.12–1.51) | 4.40E−04 | 6.86E−02 | Depression |
| cg09040942 | Body | 7 | PTPRN2 | 1.27E−01 | −0.41 (−0.66 to −0.16) | 0.66 (0.52–0.85) | 1.11E−03 | 1.40E−01 | Depression |
| cg17200577 | Body | 10 | PARD3 | 1.07E−01 | −0.35 (−0.56 to −0.14) | 0.71 (0.57–0.87) | 1.12E−03 | 1.40E−01 | Depression |
| cg16010433 | TSS1500 | 19 | HCN2 | 1.12E−01 | −0.36 (−0.58 to −0.14) | 0.7 (0.56–0.87) | 1.20E−03 | 1.40E−01 | Depression |
| cg00716277 | Body | 7 | PTPRN2 | 5.07E−02 | −0.16 (−0.26 to −0.06) | 0.85 (0.77–0.94) | 1.62E−03 | 1.41E−01 | Depression |
| cg22517801 | Body | 7 | PTPRN2 | 8.17E−02 | −0.26 (−0.42 to −0.1) | 0.77 (0.66–0.91) | 1.63E−03 | 1.41E−01 | Depression |
| cg09742643 | Body | 7 | PTPRN2 | 7.84E−02 | 0.29 (0.14–0.44) | 1.34 (1.15–1.56) | 2.11E−04 | 5.54E−02 | PTSD |
| cg05328339 | Body | 7 | PTPRN2 | 5.49E−02 | −0.2 (−0.3 to −0.09) | 0.82 (0.74–0.92) | 3.48E−04 | 5.54E−02 | PTSD |
| cg26114452 | Body | 5 | PCDHGA4 | 7.41E−02 | −0.26 (−0.41 to −0.12) | 0.77 (0.66–0.89) | 3.56E−04 | 5.54E−02 | PTSD |
| cg22420514 | Body | 7 | PTPRN2 | 3.97E−02 | 0.12 (0.04–0.2) | 1.13 (1.05–1.22) | 2.04E−03 | 1.70E−01 | PTSD |
| cg23375968 | Body | 7 | PTPRN2 | 3.96E−02 | 0.12 (0.04–0.2) | 1.13 (1.04–1.22) | 2.18E−03 | 1.70E−01 | PTSD |
| cg08395122 | Body | 5 | PCDHGA4 | 2.07E−01 | −0.61 (−1.02 to −0.2) | 0.54 (0.36–0.82) | 3.24E−03 | 2.05E−01 | PTSD |
| cg18878616 | Body | 5 | PCDHGA1 | 9.59E−02 | 0.28 (0.09–0.47) | 1.32 (1.1–1.6) | 3.60E−03 | 2.05E−01 | PTSD |
| cg05149776 | Body | 5 | PCDHGA4 | 5.79E−02 | 0.17 (0.05–0.28) | 1.18 (1.05–1.32) | 4.09E−03 | 2.05E−01 | PTSD |
| cg04214710 | Body | 7 | PTPRN2 | 2.84E−01 | −0.76 (−1.32 to −0.2) | 0.47 (0.27–0.81) | 7.34E−03 | 3.26E−01 | PTSD |
| cg12877853 | Body | 7 | PTPRN2 | 2.37E−01 | −0.63 (−1.1 to −0.17) | 0.53 (0.33–0.85) | 7.56E−03 | 3.26E−01 | PTSD |
Chr = chromosome, CI = confidence interval, CpGs = cytosine-phosphate-guanine sites, DNAm = DNA methylation, FDR-P = false discovery rate-corrected P value, OR = odds ratio, PTSD = post-traumatic stress disorder, SE = standard error.