Table 2.
Sensitivity analysis and expression quantitative trait loci mendelian randomization results of the 4 putative causal cytosine-phosphate-guanine sites.
| CpG | Gene | Q-P | Egger-P |
P† (depression) |
Beta 95% CI† (depression) |
P† (PTSD) |
Beta 95% CI† (PTSD) |
|---|---|---|---|---|---|---|---|
| cg12317217 | PCDHA2* | – | – | – | – | – | – |
| cg12661624 | PTPRN2 | 0.70 | – | .04‡ | 0.02 (0.0004–0.04) | .67 | −0.02 (−0.12 to 0.08) |
| cg24526596 | DLGAP2* | 0.62 | 0.92 | – | – | – | – |
| cg00157656 | ERICH1 | – | – | .91 | −0.001 (−0.03 to 0.03) | .76 | 0.02 (−0.12 to 0.17) |
CI = confidence interval, CpG = cytosine-phosphate-guanine, Egger-P = Mendelian randomization-Egger intercept test P-value, eQTL = expression quantitative trait loci, MR = Mendelian randomization, PTSD = post-traumatic stress disorder, Q-P = Cochran Q test P-value.
Indicates no available information from the eQTLGen consortium (phase I) for this gene.
Represents the eQTL MR analysis results.
Indicates statistical significance.