. 2026 Apr 7;17:1783172. doi: 10.3389/fmicb.2026.1783172

TABLE 2.

Distribution of virulence genes among Enterococcus faecium isolates according to linezolid resistance gene profiles.

Category	Virulence gene	Negative isolate n (%)	Linezolid resistance gene positive isolates			P-value
			One gene n (%)	Two genes n (%)	Three genes n (%)	neg vs. one	neg vs. two	neg vs. three
Adherence	ACI49664	1,476 (74.1)	85 (67.5)	59 (64.8)	25 (96.2)	0.052^a	0.028^a ^*	0.011^a ^*
Adherence	ACI49667	1,297 (65.1)	69 (54.8)	53 (58.2)	25 (96.2)	0.011^a ^*	0.120^a	0.003^a ^*
Adherence	ACI49668	1,116 (56.0)	78 (61.9)	59 (64.8)	3 (11.5)	0.270^a	0.130^a	< 0.0001^a ^*
Adherence	ACI49669	1,101 (55.3)	81 (64.3)	59 (64.8)	3 (11.5)	0.071^a	0.090^a	< 0.0001^a ^*
Adherence	ACI49670	1,130 (56.7)	79 (62.7)	59 (64.8)	3 (11.5)	0.260^a	0.160^a	< 0.0001^a ^*
Adherence	ACI49672	1,449 (72.7)	88 (69.8)	57 (62.6)	8 (30.8)	0.330^a	0.018^a ^*	< 0.0001^a ^*
Adherence	ACI49673	1,157 (58.1)	81 (64.3)	59 (64.8)	3 (11.5)	0.240^a	0.270^a	< 0.0001^a ^*
Adherence	EFME1162_RS23495	155 (7.8)	3 (2.4)	1 (1.1)	0 (0)	0.014^a ^*	0.006^a ^*	0.600^a
Adherence	Acm	1,302 (65.4)	63 (50.0)	57 (62.6)	26 (100.0)	0.0003^a ^*	0.450^a	0.001^a ^*
Adherence	bee2	164 (8.2)	27 (21.4)	30 (33.0)	0 (0)	< 0.0001^a ^*	<0.0001^a ^*	0.120^a
Adherence	bee3	161 (8.1)	27 (21.4)	30 (33.0)	0 (0)	< 0.0001^a ^*	<0.0001^a ^*	0.140^a
Adherence	ecbA/fss3	896 (45.0)	24 (19.0)	21 (23.1)	22 (84.6)	< 0.0001^a ^*	<0.0001^a ^*	< 0.0001^a ^*
Adherence	pilA	1,343 (67.4)	87 (69.0)	57 (62.6)	8 (30.8)	0.910^a	0.230^a	< 0.0001^a ^*
Adherence	sgrA	1,098 (55.1)	33 (26.2)	30 (33.0)	24 (92.3)	< 0.0001^a ^*	<0.0001^a ^*	< 0.0001^a ^*
Adherence	srt1	165 (8.3)	27 (21.4)	28 (30.8)	0 (0)	< 0.0001^a ^*	<0.0001^a ^*	0.220^a
Adherence	srt2	161 (8.1)	27 (21.4)	28 (30.8)	0 (0)	< 0.0001^a ^*	<0.0001^a ^*	0.250^a
Adherence	Tuf	1,756 (88.2)	123 (97.6)	89 (97.8)	26 (100)	0.003^a ^*	0.012^a ^*	0.170^a
Adherence	Tufa	197 (9.9)	3 (2.4)	2 (2.2)	0 (0)	0.003^a ^*	0.012^a ^*	0.190^a
Stress survival	Bsh	1,808 (90.8)	120 (95.2)	89 (97.8)	26 (100)	0.220^a	0.048^a ^*	0.300^a

Data are presented as n (%). Percentages for virulence gene–negative isolates were calculated based on the total number of genomes analyzed (n = 1,992). Percentages for linezolid resistance gene–positive groups were calculated within each corresponding subgroup.

^aP-values were calculated using the χ²-test or Fisher’s exact test, as appropriate.

* Statistically significant (P < 0.05). Gene names are presented in italics according to standard bacterial gene nomenclature.