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. 2026 Mar 20;57(2):566–572. [Article in Chinese] doi: 10.12182/20260360104

表 3. The influence of hepatitis B virus on the sleep patterns in female patients.

乙型肝炎病毒对女性患者睡眠情况的影响

Group n Subjective sleep
quality
Sleep onset
latency
Actual sleep
duration
Sleep
efficiency
Sleep
disorders
Daytime
dysfunction
Hypnotic
drug use
PSQI
score
 ULN: upper limit of normal; PSQI score: Pittsburgh Sleep Quality Index score. * P < 0.05, vs. low replication group; # P < 0.05, vs. medium replication group.
Control 30 0.99 ± 0.09 1.04 ± 0.12 0.95 ± 0.11 0.83 ± 0.09 1.01 ± 0.09 0.95 ± 0.08 0.73 0.11 6.51 ± 0.23
ALT normal
 Low replication 33 1.02 ± 0.13 1.03 ± 0.13 0.93 ± 0.10 0.86 ± 0.10 1.00 ± 0.08 0.97 ± 0.10 0.74 ± 0.13 6.56 ± 0.25
 Medium replication 34 1.00 ± 0.13 1.04 ± 0.10 0.96 ± 0.09 0.87 ± 0.10 1.02 ± 0.09 0.97 ± 0.09 0.75 ± 0.13 6.62 ± 0.22
 High replication 30 1.01 ± 0.13 1.02 ± 0.11 0.93 ± 0.11 0.88 ± 0.13 1.00 ± 0.09 0.96 ± 0.10 0.73 ± 0.16 6.49 ± 0.25
 F 0.264 0.944 0.927 0.104 0.744 0.266 0.216 2.019
 P 0.768 0.393 0.399 0.901 0.478 0.767 0.806 0.138
ULN ≤ ALT < 2 ULN
 Low replication 31 1.23 ± 0.10 1.29 ± 0.13 1.36 ± 0.15 1.18 ± 0.17 1.37 ± 0.18 1.23 ± 0.18 1.02 ± 0.26 8.68 ± 0.47
 Medium replication 34 1.19 ± 0.11 1.29 ± 0.12 1.34 ± 0.13 1.15 ± 0.16 1.40 ± 0.17 1.21 ± 0.18 1.02 ± 0.24 8.69 ± 0.47
 High replication 34 1.21 ± 0.12 1.29 ± 0.12 1.34 ± 0.11 1.17 ± 0.14 1.36 ± 0.17 1.21 ± 0.15 1.03 ± 0.13 8.62 ± 0.39
 F 0.816 0.034 0.180 0.261 0.494 0.119 0.063 0.290
 P 0.445 0.967 0.836 0.771 0.612 0.888 0.939 0.749
2 ULN ≤ ALT
 Low replication 36 1.52 ± 0.17 1.72 ±0.24 1.56 ± 0.22 1.59 ± 0.23 1.89 ± 0.19 1.58 ± 0.18 1.19 ± 0.23 11.02 ± 0.52
 Medium replication 38 1.85 ± 0.23* 1.92 ± 0.22* 1.86 ± 0.19* 1.96 ± 0.18* 2.11 ± 0.19* 1.94 ± 0.21* 1.50 ± 0.23* 13.15 ± 0.48*
 High replication 36 2.26 ± 0.34*, # 2.28 ± 0.30*, # 2.23 ± 0.22*, # 2.28 ± 0.26*, # 2.53 ± 0.31*, # 2.33 ± 0.25*, # 2.04 ± 0.28*, # 15.93 ± 0.71*, #
 F 77.134 42.870 94.813 84.358 66.774 114.584 108.254 656.544
 P < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001