表 2. The effect of SBT on inflammatory expression, collagen deposition, and matrix metalloproteinases (MMPs) in rats with pulmonary fibrosis.

SBT对肺纤维化大鼠炎症表达、胶原沉积状态、MMP的影响

Index	Sham	Model	PFD	SBT-L	SBT-M	SBT-H
IL: interleukin; TNF-α: tumor necrosis factor alpha; PFD: pirfenidone. ## P < 0.01, ### P < 0.001, #### P < 0.0001, vs. the Sham group; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, vs. the model group. n = 5.
Inflammation score	1.00 ± 0.71	3.60 ± 0.55###	2.60 ± 0.55	2.00 ± 0.71	1.60 ± 0.55*	1.40 ± 0.55**
IL-18/(pg/mL)	67.40 ± 3.68	154.98 ± 11.09##	89.51 ± 9.11	113.55 ± 5.34	87.49 ± 2.29	75.39 ± 7.16*
TNF-α/(pg/mL)	175.69 ± 8.99	256.36 ± 10.83####	173.99 ± 8.43****	237.32 ± 3.71	214.71 ± 7.43***	169.00 ± 7.64****
Collagen volume fraction/%	6.15 ± 0.21	16.77 ± 0.96####	12.03 ± 1.23****	10.21 ± 0.32****	8.85 ± 0.42****	7.11 ± 1.19****
Hydroxyproline/(μg/mg)	1.00 ± 0.08	1.57 ± 0.01##	1.46 ± 0.05	1.37 ± 0.08	1.18 ± 0.02	1.05 ± 0.08*
MMP-2/(ng/mL)	135.02 ± 20.12	310.33 ± 9.06####	138.88 ± 22.67****	163.88 ± 4.89****	150.31 ± 4.18****	131.47 ± 2.32****
MMP-9/(ng/mL)	34.50 ± 3.43	89.87 ± 3.42####	55.91 ± 6.50****	72.95 ± 4.48**	57.91 ± 2.28****	49.88 ± 4.09****