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. 2026 Apr 20;16:12870. doi: 10.1038/s41598-026-48841-4

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Loss of Ca_v1.2 in PV⁺ neurons promotes anxiety-related behavior. a Distance travelled in 5-min segments across 30-min duration and total distance travelled during OFT. b Time spent in and number of entries into the inner zone of OF arena. c Percentage time spent in and number of entries into the lit zone of LDB. d Percentage time spent in and number of entries into the open arms of elevated plus maze. The p values are from student´s t test, ^*p < 0.05, ^**p < 0.01, data are presented as mean ± S.E.M.(Ctrl^PV: n = 16, CKO^PV: n = 19).