Fig. 5.

Loss of Ca_v1.2 in PV⁺ or excitatory neurons activates distinct stress-responsive brain regions. a Stress responsive brain regions selected for cFos quantification. For abbreviations see Supplementary Fig. 1. b Representative images of cFos activation in Ca_v1.2-PV (nucleus accumbens, NAc; lateral habenular nucleus, LHbN; paraventricular thalamic nucleus, PVT) and Ca_v1.2-Nex (lateral septum, LS) mice. Altered cFos expression in c NAc, d LHbN, e PVT in Ca_v1.2-PV mice and in f LS in Ca_v1.2-Nex mice. Scale bar: 20 μm. The p values are from student’s t test, ^*p < 0.05, data are presented as mean ± S.E.M. (c–e Ctrl^PV: n = 5, CKO^PV: n = 5; f Ctrl^Nex: n = 6, CKO^Nex: n = 6).